Home l Contact us l Feedback l Sitemap     
Sleep Apnea Research
9/11 Rx |Seminars | Sleep Apnea | ZHT for Apnea | Investors l Partners l Providers | Disclaimer | About us
Sleep Apnea Linked to top 10 Medical killings as Main Public Health Risk and Concerns
 

Sleep apnea, sleep-disordered breathing, and intermittent hypoxia have been identified and linked in latest research to almost all major fatal medical conditions, from heart attack, stroke, diabetes, COPD cancer, and major depressive disorders.

Current main-stream treatment options are unsatisfactory, and the entire world is looking for a better or best solution.

This market is one of the most explosive and largely untapped markets.

SleepApneaUSA.net, founded by Dr. Jin Zhou, relied upon the latest research and clinically developed ZHT - Zhou's Hypoxicology Therapy to discover a possible cure for sleep apnea and provide an alternative care to those who can't tolerate CPAP,"sleeping mask".

 
We are looking for visionary investors, strategic partners, business alliance and concerned healthcare providers to advance our goals, to find and provide with possible cure for sleep apnea, and its related major fatal medical conditions.

This web site is mainly for visionary investors, strategic business partners and concerned healthcare providers.

 
 
N C H S home page graphic
 

What's New graphic
Health, United States logo
Health, United States, 2005 With Chartbook on Trends in the Health of Americans (12/2005)
News Release

News Releases and Fact Sheets

bullet graphicDeaths: Preliminary Data for 2003 (2/2005)
View/download PDF 1.3 MB

Data Highlights

bullet graphicLeading Causes of Death
View/download PDF 170 KB

 
Top 10 Links graphic

bulletHelp obtaining birth, death, marriage, or divorce certificates

bulletFASTSTATS A to Z

bulletCDC Growth Charts

bulletNHANES

bulletDeaths/Mortality

bulletICD Information

bulletBirths/Natality

bulletData Warehouse

bulletNational Vital Statistics System

bulletHealth E-Stat on Obesity

 

Deaths: Preliminary Data for 2003
View/download PDF 1.3 MB


"Causes of death

The 15 leading causes (table B) remainedthe same for 2002 and 2003 except that Assault (homicide)dropped out of the 15 leading causes in 2003 and Parkinson’s disease entered the list as the 14th leading cause. The 15 leading causes of death in 2003 were as follows:

1) Diseases of heart;
2) Malignant neoplasms;
3) Cerebrovascular diseases;
4) Chronic lower respiratory diseases;
5) Accidents (unintentional injuries);
6) Diabetes mellitus;
7) Influenza and pneumonia;
8) Alzheimer’s disease;
9) Nephritis, nephrotic syndrome and nephrosis;
10) Septicemia;
11) Intentional self-harm (suicide);
12) Chronic liver disease and cirrhosis;
13) Essential (primary) hypertension and hypertensive renal disease;
14) Parkinson’s disease;
15) Pneumonitis due to solids and liquids."

 

The New England Journal of Medicine

November 10, 2005

Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure
T. D. Bradley and Others

Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
H. K. Yaggi and Others

Mechanisms of Disease: Acute Oxygen-Sensing Mechanisms
E. K. Weir, J. López-Barneo, K. J. Buckler, and S. L. Archer

Sleep — A New Cardiovascular Frontier
V. K. Somers,

 
American Academy of Sleep Medicine - Clinical Practice Parameters
 
yawning.info
http://baillement.com/
http://Yawning.info/

Yawning: unsuspected avenue for a better understanding of arousal and interoception

Abstract in English

Yawning : its cycles, its roles (pdf)

Fetal yawning assessed by 3D and 4D sonography

Why do people yawn ?

The neural basis of contagious yawning

Contagious yawning: the role of self-awareness and mental state attribution

Yearning to yawn: the neural basis of contagious yawning

Empathy and contagion of yawning

Examining the connection between yawning and depression

Varia in english

 
 

Sleep Apnea News Sleep Apnea Research ZHT News

SleepApneaUSA.net on Sleep Apnea related Research:

The followings are from NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM) and many other online academic and scientific resources.

 
Peled N, Kassirer M, Shitrit D, Kogan Y, Shlomi D, Berliner AS, Kramer MR.

Related Articles,
Links
Abstract The association of OSA with insulin resistance, inflammation and metabolic syndrome.
Respir Med. 2007 Aug;101(8):1696-701. Epub 2007 Apr 26.
PMID: 17466499 [PubMed - in process]
 
Savransky V, Nanayakkara A, Li J, Bevans S, Smith PL, Rodriguez A, Polotsky VY.

Related Articles,
Links
Abstract Chronic intermittent hypoxia induces atherosclerosis.
Am J Respir Crit Care Med. 2007 Jun 15;175(12):1290-7. Epub 2007 Mar 1.
PMID: 17332479 [PubMed - in process]
 
Verhulst SL, Schrauwen N, Haentjens D, Rooman RP, Van Gaal L, De Backer WA, Desager KN.

Related Articles,
Links
Abstract Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents.
J Pediatr. 2007 Jun;150(6):608-12.
PMID: 17517244 [PubMed - indexed for MEDLINE]
 
Ryan S, Nolan GM, Hannigan E, Cunningham S, Taylor C, McNicholas WT.

Related Articles,
Links
Abstract Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity.
Thorax. 2007 Jun;62(6):509-14. Epub 2007 Jan 24.
PMID: 17251313 [PubMed - in process]
 
Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP, Polotsky VY.

Related Articles,
Links
Abstract Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia.
J Appl Physiol. 2007 Feb;102(2):557-63. Epub 2006 Nov 2.
PMID: 17082365 [PubMed - indexed for MEDLINE]
 
Jennings JR, Muldoon MF, Hall M, Buysse DJ, Manuck SB.

Related Articles,
Links
Abstract Self-reported sleep quality is associated with the metabolic syndrome.
Sleep. 2007 Feb 1;30(2):219-23.
PMID: 17326548 [PubMed - indexed for MEDLINE]
5:
McGuire M, Macdonald SM, Song G, Poon CS.

Related Articles,
Links
Abstract Phrenic long-term facilitation is robust to hypercapnia and hypocapnia but not hyperventilatory hypotension under PEEP.
Respir Physiol Neurobiol. 2007 Aug 15;158(1):107-11. Epub 2007 Feb 3.
PMID: 17331813 [PubMed - in process]
6:
Peled N, Kassirer M, Shitrit D, Kogan Y, Shlomi D, Berliner AS, Kramer MR.

Related Articles,
Links
Abstract The association of OSA with insulin resistance, inflammation and metabolic syndrome.
Respir Med. 2007 Aug;101(8):1696-701. Epub 2007 Apr 26.
PMID: 17466499 [PubMed - in process]
7:
Subramanian HH, Balnave RJ, Chow CM.

Related Articles,
Links
Abstract Ventilation induced apnea and its effect on dorsal brainstem inspiratory neurones in the rat.
Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):252-61. Epub 2007 Feb 14.
PMID: 17369108 [PubMed - in process]
8:
Palada I, Obad A, Bakovic D, Valic Z, Ivancev V, Dujic Z.

Related Articles,
Links
Abstract Cerebral and peripheral hemodynamics and oxygenation during maximal dry breath-holds.
Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):374-81. Epub 2007 Feb 8.
PMID: 17363344 [PubMed - in process]
2:
Ristagno G, Tang W, Sun S, Weil MH.

Related Articles,
Links
Abstract Spontaneous gasping produces carotid blood flow during untreated cardiac arrest.
Resuscitation. 2007 Jun 15; [Epub ahead of print]
PMID: 17574323 [PubMed - as supplied by publisher]

In The Sept 06 Issue of Archives of Internal Medicinen in JAMA & Archivers
In This Issue of Archives of Internal Medicine

Arch Intern Med. 2006;166:1685.
FULL TEXT | PDF

Editorials
Sleep and Health: Everywhere and in Both Directions
Phyllis C. Zee; Fred W. Turek
Arch Intern Med. 2006;166:1686-1688.
EXTRACT | FULL TEXT | PDF

"This special issue of the ARCHIVES is devoted to original investigations that further our understanding of the relationship of sleep and health. The theme that emerges throughout this issue is that sleep serves as an indicator of health and quality of life and therefore is highly and directly relevant to the practice of medicine.......As evidenced by this issue of the ARCHIVES, sleep is making its way into the mainstream of medicine, but it is also quite clear that much more research is needed to understand the mechanisms that link sleep to health and to the development of safer and more effective treatments for sleep disorders."

Arch Intern Med -- Table of Contents (Vol. 166 No. 16, September 18, 2006)

 

 
1: Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, Sahadevan J, Redline S. Related Articles, Links
Abstract Association of Nocturnal Arrhythmias with Sleep-disordered Breathing: The Sleep Heart Health Study.
Am J Respir Crit Care Med. 2006 Apr 15;173(8):910-6. Epub 2006 Jan 19.
PMID: 16424443 [PubMed - in process]

"Conclusions: Individuals with severe sleep-disordered breathing have two- to fourfold higher odds of complex arrhythmias than those without sleep-disordered breathing even after adjustment for potential confounders."

CPAP Merely Palliative in Obstructive Sleep Apnea Medscape (subscription)]

"NEW YORK (Reuters Health) Dec 21 - Treating obstructive sleep apnea (OSA) with nasal continuous positive airway pressure (CPAP) "is not a solution to the problem," researchers report in the December issue of the Annals of Neurology. The real problem is the underlying neurological lesions that cause disordered breathing and the solution, they say, is prevention of progression of OSA....

Summing up, he added that it is important to know the size and extent of the underlying neurological lesion before surgery. It is also "important to realize that nasal CPAP is not a complete solution and that non-compliance is a major problem... surgery may be a better solution."

Is obstructive sleep apnea syndrome a neurological disorder? A continuous positive airway pressure follow-up study.
Ann Neurol. 2005 Dec;58(6):880-7.

PMID: 16240364 [PubMed - in process]
Guilleminault C, Huang YS, Kirisoglu C, Chan A.

“Over 5 years, we managed healthy, nonobese subjects compliant with nasal CPAP...... By the completion of the study, all subjects required an increase in nasal CPAP (1-7cm H(2)O) and demonstrated abnormal two-point palatal discrimination compared with control subjects. Despite initial control of clinical symptoms with regular usage of nasal CPAP in subjects without weight change, abnormal sensory palatal evaluation was present at the conclusion of the study. Obstructive sleep apnea syndrome involves abnormal upper airway sensory input, which may be responsible for the development of apneas and hypopneas. These neurological lesions are persistent despite nasal CPAP treatment. Ann Neurol 2006.”

Respiration. 2005 Dec 8; [Epub ahead of print] Related Articles, Books

Sleep Apnoea-Hypopnoea Index Is an Independent Predictor of High-Sensitivity C-Reactive Protein Elevation.

Zouaoui Boudjeltia K, Van Meerhaeghe A, Doumit S, Guillaume M, Cauchie P, Brohee D, Vanhaeverbeek M, Kerkhofs M
PMID: 16369126 [PubMed - as supplied by publisher]
   
 
Expert Opin Pharmacother. 2006 Jan;7(1):11-23. Related Articles, Books

Pharmacological management of sleep apnoea.

Abad VC, Guilleminault C.

Clinical Monitoring Sleep Disorders Center, Camino Medical Group, Palo Alto Medical Foundation, Cupertino, CA, USA.
"Some of these drugs have received very little testing and are the subject of few research articles."
 
Rev Mal Respir. 2005 Feb;22(1 Pt 1):93-101. Related Articles, Books, LinkOut

Erratum in:
  • Rev Mal Respir. 2005 Apr;22(2 Pt 1):256.

[Manual abdominal compression for the detection of expiratory flow limitation]
[Article in French]

Abdel Kafi S, Leduc D, Sergysels R, Ninane V.

"CONCLUSIONS: MCA is a reliable technique for the detection of EFL in different positions, during resting breathing or exercise, requiring neither special equipment nor patient cooperation."
   
 
Laryngoscope. 2005 Dec;115(12):2109-2113. Related Articles, Books

Does Severity of Obstructive Sleep Apnea/Hypopnea Syndrome Predict Uvulopalatopharyngoplasty Outcome?

Friedman M, Vidyasagar R, Bliznikas D, Joseph N.
PMID: 16369152 [PubMed - as supplied by publisher] 
   
 
Am J Hypertens. 2005 Nov;18(11):1489-95. Related Articles, Books, LinkOut
http://www.ncbi.nlm.nih.gov/entrez/utils/lofref.fcgi?PrId=3048&uid=16280287&db=PubMed&url=http://linkinghub.elsevier.com/retrieve/pii/S0895-7061(05)00996-9 
Nocturnal hypoxia is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population.

Eguchi K</ b>, Kario K, Hoshide S, Ishikawa J, Morinari M, Shimada K.
PMID: 16280287 [PubMed - indexed for MEDLINE]
   
  Blood pressure evolution after acute ischemic stroke in patients with and without sleep apnea.
Stroke. 2005 Dec;36(12):2614-8. Epub 2005 Nov 10.
PMID: 16282549 [PubMed - indexed for MEDLINE]
   
 
  Poreba R, Derkacz A, Andrzejak R. Related Articles, Links
[Sleep apnea syndrome as a cause of secondary hypertension. A case report.]
Kardiol Pol. 2005 Nov;63(5):549-51. Polish.
PMID: 16362859 [PubMed - in process]
   
 
  Puhan MA, Suarez A, Cascio CL, Zahn A, Heitz M, Braendli O. Related Articles, Links
Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial.
BMJ. 2005 Dec 23; [Epub ahead of print]
PMID: 16377643 [PubMed - as supplied by publisher]
   
 

 

Chen H, Zhang X.

Related Articles, Links

[The of cervical circumference, lingual height and lingual width on the obstructive sleep apnea-hypopnea syndrome]
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Sep;19(18):822-3. Chinese.
PMID: 16375110 [PubMed - in process]

   
 

 

Pepin JL, Chouri-Pontarollo N, Tamisier R, Levy P.

Related Articles, Links

Cheyne-Stokes respiration with central sleep apnoea in chronic heart failure: Proposals for a diagnostic and therapeutic strategy.
Sleep Med Rev. 2005 Dec 21; [Epub ahead of print]
PMID: 16376589 [PubMed - as supplied by publisher]

   
 
  McIver KL, Evans C, Kraus RM, Ispas L, Sciotti VM, Hickner RC. Related Articles, Links
NO-mediated alterations in skeletal muscle nutritive blood flow and lactate metabolism in fibromyalgia.
Pain. 2005 Dec 20; [Epub ahead of print]
PMID: 16376018 [PubMed - as supplied by publisher]

"In conclusion: (1) There is reduced nutritive flow response to aerobic exercise and reduced maximal exercise time in FM that might relate to higher iNOS protein content and contribute to exertional fatigue in FM; (2) The increased dialysate lactate in FM in response to stimulation of NOS or a nitric oxide donor suggest that FM may be more sensitive than HC to the suppressive effect of nitric oxide on oxidative phosphorylation."

   
 
  Connolly DM, Hosking SL. Related Articles, Links
Aviation-related respiratory gas disturbances affect dark adaptation: A reappraisal.
Vision Res. 2005 Dec 19; [Epub ahead of print]
PMID: 16375944 [PubMed - as supplied by publisher
   
   
 
Alonso-Fernandez A, Garcia-Rio F, Arias MA, Mediano O, Pino JM, Martinez I, Villamor J. Related Articles, Links
Abstract Obstructive sleep apnoea-hypoapnoea syndrome reversibly depresses cardiac response to exercise.
Eur Heart J. 2006 Jan;27(2):207-15. Epub 2005 Nov 2.
PMID: 16267074 [PubMed - in process]

"CONCLUSION: OSAHS patients with normal resting left ventricular systolic function and no hypertension had a worse cardiac response to exercise than healthy subjects. In these patients, 3 months of CPAP improved both Qt and SV responses to exercise."

   
 
Masip J, Roque M, Sanchez B, Fernandez R, Subirana M, Exposito JA. Related Articles, Links
Abstract Noninvasive ventilation in acute cardiogenic pulmo