In The Sept 2006 Issue of Archives of Internal Medicinen in JAMA & Archivers
In This Issue of Archives of Internal Medicine
Arch Intern Med. 2006;166:1685.
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Editorials
Sleep and Health: Everywhere and in Both Directions
Phyllis C. Zee; Fred W. Turek
Arch Intern Med. 2006;166:1686-1688.
EXTRACT | FULL TEXT | PDF

"This special issue of the ARCHIVES is devoted to original investigations that further our understanding of the relationship of sleep and health. The theme that emerges throughout this issue is that sleep serves as an indicator of health and quality of life and therefore is highly and directly relevant to the practice of medicine.......As evidenced by this issue of the ARCHIVES, sleep is making its way into the mainstream of medicine, but it is also quite clear that much more research is needed to understand the mechanisms that link sleep to health and to the development of safer and more effective treatments for sleep disorders."

Arch Intern Med -- Table of Contents (Vol. 166 No. 16, September 18, 2006)

 

Original Investigations   Sleep Duration and Health in Young Adults Arch Intern Med. 2006;166:1689-1692. ABSTRACT   Shift of Monocyte Function Toward Cellular Immunity During Sleep Arch Intern Med. 2006;166:1695-1700. ABSTRACT   Sleep Duration and Body Mass Index in a Rural Population Arch Intern Med. 2006;166:1701-1705. ABSTRACT   Longitudinal Association of Sleep-Related Breathing Disorder and Depression Arch Intern Med. 2006;166:1709-1715. ABSTRACT   Sleepiness and Sleep in Patients With Both Systolic Heart Failure and Obstructive Sleep Apnea Arch Intern Med. 2006;166:1716-1722. ABSTRACT   Soluble Interleukin 6 Receptor: A Novel Marker of Moderate to Severe Sleep-Related Breathing Disorder Arch Intern Med. 2006;166:1725-1731. ABSTRACT   Consequences of Comorbid Insomnia Symptoms and Sleep-Related Breathing Disorder in Elderly Subjects Arch Intern Med. 2006;166:1732-1738. ABSTRACT   Plasma Levels of Tumor Necrosis Factor and Soluble Tumor Necrosis Factor Receptors in Patients With Narcolepsy Arch Intern Med. 2006;166:1739-1743. ABSTRACT   Allergic Rhinitis and Its Consequences on Quality of Sleep: An Unexplored Area Arch Intern Med. 2006;166:1744-1748. ABSTRACT   Impact of a Child's Chronic Illness on Maternal Sleep and Daytime Functioning Arch Intern Med. 2006;166:1749-1755. ABSTRACT   Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation Arch Intern Med. 2006;166:1756-1762. ABSTRACT   A Double-blind, Placebo-Controlled, Crossover Study of Sildenafil in Obstructive Sleep Apnea Suely Roizenblatt; Christian Guilleminault; Dalva Poyares; Fátima Cintra; Adriana Kauati; Sergio Tufik Arch Intern Med. 2006;166:1763-1767. ABSTRACT   Role of Sleep Duration and Quality in the Risk and Severity of Type 2 Diabetes Mellitus Arch Intern Med. 2006;166:1768-1774. ABSTRACT   Insomnia, Trouble Sleeping, and Complementary and Alternative Medicine: Analysis of the 2002 National Health Interview Survey Data Arch Intern Med. 2006;166:1775-1782. ABSTRACT

Snoring Costs Over $88 Billion in Lost Productivity, Health Care Costs
Insurance Journal - June 8, 2006

"Patients who suffer from snoring and sleep apnea also may be suffering from depression and anxiety, and could have trouble concentrating at work, according to a new study. The result -- a cost to the U.S. economy of more than $88 billion in lost productivity and health care costs."

Sleep apnea, sleep-disordered breathing, and intermittent hypoxia have been identified and linked in latest research to almost all major fatal medical conditions, from heart attack, stroke, diabetes, COPD cancer, and major depressive disorders.

Breathing Masks Decrease Blood Pressure in People with Sleep Apnea

"DG News - Jun 1, 2006
NEW YORK, N.Y. -- June 1, 2006 -- Patients with the nighttime breathing disorder known as obstructive sleep apnea who receive air through a mask while they sleep can significantly reduce their blood pressure, according to a study to be presented at the American Thoracic Society (ATS) International Conference on May 22nd. "

Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure.
Hypertension. 2006 May;47(5):840-5. Epub 2006 Apr 3.
PMID: 16585412 [PubMed - indexed for MEDLINE]
Norman D, Loredo JS, Nelesen RA, Ancoli-Israel S, Mills PJ, Ziegler MG, Dimsdale JE.

"We found that 2 weeks of CPAP therapy resulted in a significant reduction in daytime mean arterial and diastolic blood pressure and nighttime systolic, mean, and diastolic blood pressure (all Ps <0.05). Although nocturnal supplemental oxygen therapy improved oxyhemoglobin saturation, it did not affect blood pressure. We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation."

UAB Study Finds Link Between Sleep Apnea and High Blood Pressure (Press Releases from UAB) 11/16/2006

"Ubunama and colleagues with the UAB Hypertension Program found that the severity of sleep apnea is directly related to endothelial changes,......Sleep apnea is very under-diagnosed, according to Ubunama, particularly among patients with high blood pressure, and doctors rarely ask about their patients’ sleep habits. However, in UAB hypertension clinics, researchers have found the prevalence of sleep apnea in the population of resistant hypertension patients, specifically those who continue to experience uncontrolled high blood pressure on three or more medications, is approximately 85 percent."

Sleep Apnea, Blood Pressure Linked (Newswise) Dec 11-2005

"Ubunama's suggestions are based on results of a study funded by the National Heart, Lung and Blood Institute and presented last month at the American Heart Association annual meeting. “We found a direct relationship between the severity of sleep apnea and cardiovascular changes associated with high blood pressure.”

Sleep disorders in systolic heart failure: A prospective study of 100 male patients. The final report.
Int J Cardiol. 2006 Jan 4;106(1):21-8.
PMID: 16321661 [PubMed - in process]

"CONCLUSIONS: 49% of male patients with systolic heart failure suffer from sleep apnea and 20% have PLMS. CSA occurs in about 37%, and OSA in 12% of patients. Habitual snoring and obesity are the hallmarks of OSA. In contrast, heart failure patients with CSA are commonly thin and mostly do not snore. Hallmarks of CSA are Class III New York Heart, artrial fibrillation, frequent nocturnal ventricular arrhythmias, low arterial PCO2 and LVEF <20%."

Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis.
JAMA. 2005 Dec 28;294(24):3124-30. Review.
PMID: 16380593 [PubMed - in process]

"CONCLUSIONS: Noninvasive ventilation reduces the need for intubation and mortality in patients with acute cardiogenic pulmonary edema. Although the level of evidence is higher for CPAP, there are no significant differences in clinical outcomes when comparing CPAP vs NIPSV."

Obstructive sleep apnoea-hypoapnoea syndrome reversibly depresses cardiac response to exercise.
Eur Heart J. 2006 Jan;27(2):207-15. Epub 2005 Nov 2.
PMID: 16267074 [PubMed - in process]

"CONCLUSION: OSAHS patients with normal resting left ventricular systolic function and no hypertension had a worse cardiac response to exercise than healthy subjects. In these patients, 3 months of CPAP improved both Qt and SV responses to exercise."

Current main-stream treatment options are unsatisfactory, and the entire world is looking for a better or best solution.

SleepApneaUSA.net, founded by Dr. Jin Zhou, relied upon the latest research and clinically developed ZHT - Zhou's Hypoxicology Therapy to discover a possible cure for sleep apnea and provide an alternative care to those who can't tolerate CPAP,"sleeping mask".

By now, if you are informed or aware of, from the latest scientific discovery on the association or relationship between sleep apnea, sleep disordered breathing and heart attack, hypertension, stroke, you may think or see how ZHT (Zhou's Hypoxicology Therapy) may have potential global values and impact on entire USA health and longevity.

How do we find out such potential values for ZHT?  [Items 1 - 20 of 101 from PubMed]

[Sleep apnea syndrome as a cause of secondary hypertension. A case report.]
Kardiol Pol. 2005 Nov;63(5):549-51. Polish.
PMID: 16362859 [PubMed - in process]

We invite you to review the Health, United States, 2005, the government’s annual report to the President and Congress on the health of all Americans. The report was prepared by the Centers for Disease Control and Prevention’s (CDC), you shall make your own determinations and conclusions.

	Obesity, High Blood Pressure Impacting Many U.S. Adults Ages 55-64 (Press Release- Dec 8, 2005) CDC Press "Half of Americans aged 55-64 have high blood pressure – a major risk factor for heart disease and stroke – and two in five are obese, according to Health, United States, 2005, the government’s annual report to the President and Congress on the health of all Americans. The report was prepared by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics from data gathered by state and federal health agencies and through ongoing national surveys..... Controlling high blood pressure and obesity is crucial for health, and particularly for baby boomers as they grow older," said HHS Secretary Mike Leavitt. "It's time to act against both conditions so more Americans can live longer, healthier lives."
Dec 8, 2005
	Health, United States, 2005 with Chartbook on Trends in the Health of Americans "Mortality Trends (page 18 of 25) Life expectancy and infant mortality rates are often used to gauge the overall health of a population. Life expectancy shows a long-term upward trend and infant mortality shows a long-term downward trend. In 2003 life expectancy at birth for the total population reached a record high of 77.6 years (preliminary data), up from 75.4 years in 1990 (table 27). In 2003 the preliminary infant mortality rate was 6.9 infant deaths per 1,000 live births, similar to the rate in 2002 (7.0 per 1,000). In 2002 the infant mortality rate increased for the first time in more than 40 years. The rise in infant mortality in 2002 was concentrated among neonatal deaths occurring in the first week of life, due largely to an increase in the number of infants born weighing less than 750 grams (1 pound 10 1/2 ounces) (figure 27 and table 22). Between 1950 and 2003 the age-adjusted death rate for the total population declined 43 percent to 831 deaths per 100,000 population (preliminary data). This reduction was driven largely by declines in mortality from heart disease, stroke, and unintentional injury (figure 29 and table 29). Mortality from heart disease, the leading cause of death, declined almost 4 percent in 2003 (preliminary data), continuing a long-term downward trend. The 2003 age-adjusted death rate for heart disease was 60 percent lower than the rate in 1950 (figure 29 and tables 29 and 31). Mortality from cancer, the second leading cause of death, decreased more than 2 percent in 2003 (preliminary data), continuing the decline that began in 1990. Overall cancer age-adjusted death rates rose from 1960 to 1990 and then reversed direction (figure 29 and tables 29 and 31). Mortality from stroke, the third leading cause of death, declined almost 5 percent in 2003 (preliminary data). Between 1950 and 2003, the age-adjusted death rate for stroke declined 70 percent (figure 29 and tables 29 and 31). In 2003 mortality from chronic lower respiratory diseases (CLRD), the fourth leading cause of death, decreased almost 5 percent from its peak in 1999 (preliminary data). Age-adjusted death rates for CLRD generally rose between 1980 and 1999, mainly as a result of steadily increasing death rates for females, most noticeably for females age 55 years and over (figure 29 and tables 29, 31, and 41). Mortality from unintentional injuries, the fifth leading cause of death, decreased more than 2 percent in 2003 (preliminary data). Age-adjusted death rates for unintentional injuries generally declined from 1950 until 1992 and then increased slightly (figure 29 and tables 29 and 31)."
	For Immediate Release: February 28, 2005 Contact: CDC National Center for Health Statistics Press Office, (301) 458-4800 E-mail: nchsquery@cdc.gov Deaths: Preliminary Data for 2003. NVSR Volume 53, Number 15. 48 pp. (PHS) 2004-1120 View/download PDF 1.3 MB [Page 3 of 48] "Causes of death The 15 leading causes(table B) remainedthe same for 2002 and 2003 except that Assault (homicide)dropped out of the 15 leading causes in 2003 and Parkinson’s disease entered the list as the 14th leading cause. The 15 leading causes of death in 2003 were as follows: 1) Diseases of heart; 2) Malignant neoplasms; 3) Cerebrovascular diseases; 4) Chronic lower respiratory diseases; 5) Accidents (unintentional injuries); 6) Diabetes mellitus; 7) Influenza and pneumonia; 8) Alzheimer’s disease; 9) Nephritis, nephrotic syndrome and nephrosis; 10) Septicemia; 11) Intentional self-harm (suicide); 12) Chronic liver disease and cirrhosis; 13) Essential (primary) hypertension and hypertensive renal disease; 14) Parkinson’s disease; 15) Pneumonitis due to solids and liquids."
Dec 8, 2005	Health, United States, 2005 with Chartbook on Trends in the Health of Americans Trend Tables The chartbook section is followed by 156 trend tables organized around four major subject areas: health status and determinants, health care utilization, health care resources, and health care expenditures. Overall He...
Dec 8, 2005	Health, United States, 2005 with Chartbook on Trends in the Health of Americans Trend Tables The chartbook section is followed by 156 trend tables organized around four major subject areas: health status and determinants, health care utilization, health care resources, and health care expenditures. Tables are...
Dec 23, 2005	Notice to Readers: Publication of Health, United States, 2005   Vol 54, No MM50;1288 CDC's National Center for Health Statistics has published Health, United States, 2005, the 29th edition of the annual report on the nation's health. The report includes 156 detailed trend tables organized around four broad subject... [PDF Version]
Dec 22, 2005	National Center for Health Statistics Health, United States, 2005 With Chartbook on Trends in the Health of Americans (12/2005) News Release Births, Marriages, Divorces, and Deaths: Provisional Data for May 2005 (12/2005) View/download PDF 211 KB Fertility, Family Pla...

SleepApneaUSA.net: ZHT for USA???

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CPAP Merely Palliative in Obstructive Sleep Apnea [(Reuters Health) Dec 21]